What is a REMS?A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program. The U.S. Food and Drug Administration (FDA) can require a REMS for certain medications. The purpose of a REMS is to reduce the number or seriousness of injuries related to the use of the medication.

How to say REMS in English

What are TIRF medicines? A transmucosal immediate-release fentanyl (TIRF) medicine is a prescription medicine that contains fentanyl, a very strong opioid pain reliever.

What is Opioid Tolerant? Patients considered opioid tolerant are those who are taking around-the-clock medicine consisting of at least 60 mg of oral morphine per day, or at least 25 mcg per hour of transdermal fentanyl, or at least 30 mg of oral oxycodone per day, or at least 8 mg of oral hydromorphone per day, or at least 25 mg oral oxymorphone per day, or at least 60 mg oral hydrocodone per day or an equianalgesic dose of another opioid medication daily for a week or longer. Patients must remain on around-the- clock opioids when taking a TIRF medicine.

What is Naloxone?Naloxone is a medicine that helps reverse an opioid overdose.