To receive treatment, a patient must be enrolled in the TIRF REMS by a certified doctor.

How do patients enroll in the TIRF REMS?


Talk with your TIRF REMS Certified doctor

Receive counseling from your doctor on the safe use of TIRF medicines using the Patient Counseling Guide and the appropriate Medication Guide.

Make sure you understand

You must do the following:
  • Take around-the-clock opioid pain medicine when using TIRF medicines
  • Do not share TIRF medicines
  • Properly store and dispose of your TIRF medicines
You must inform the doctor of serious adverse events
  • Accidental exposure
  • Abuse
  • Misuse
  • Addiction
  • Overdose
You must receive counseling from the doctor on the safe use of each new TIRF medicine you are prescribed.


Together with your doctor, complete and sign the Patient Enrollment Form. Your doctor or their staff can assist you in completing the enrollment either online or by using the paper form.